Dupilumab
What Is Dupilumab?
Dupilumab is a biologic medication designed that is FDA-approved for atopic dermatitis (eczema) and prurigo nodularis. It specifically target certain immune system components which contribute to atopic dermatitis and prurigo nodularis. It is also being studied for chronic idiopathic urticaria.
The decision on which biologic to use is influenced by various factors, such as:
Concurrent medical conditions
Affected eczema areas (how much body surface area affected, how severe the itching is)
Typically, these medications are considered for patients who haven't achieved satisfactory results with topical treatments.
How does Dupilumab Work?
Dupilumab works by specifically targeting and blocking the action of two key proteins, interleukin-4 (IL-4) and interleukin-13 (IL-13), which are central to the inflammatory processes involved in these conditions. By inhibiting these proteins, Dupilumab helps to reduce the inflammatory response that can lead to the symptoms of itching, swelling, and other allergic-type reactions associated with the conditions it treats.
What are Possible Side Effects of Dupilumab?
As with any medication, Dupilumab can cause side effects, although not everyone experiences them. Common side effects include:
Injection site reactions (e.g., redness, swelling, itching)
Eye and eyelid inflammation, including redness, swelling, and itching
Cold sores in your mouth or on your lips
Less common but more serious side effects can occur, including allergic reactions, eye problems, and infections. It is important to discuss the potential for side effects with your healthcare provider, who can offer strategies to manage them and decide whether Dupilumab is right for you.
How is Dupilumab Used?
Dupilumab is administered via subcutaneous injection. The frequency of the injections will depend on the specific condition being treated and the individual treatment plan prescribed by your healthcare provider. Typically, it is first administered as a loading dose, followed by regular doses every other week. The administration can often be performed at home after proper training on how to inject Dupilumab safely.
These medications necessitate refrigeration.
They should be taken out approximately 30 minutes prior to injection for optimal use.
While effective in symptom management, these biologics don't cure atopic dermatitis. If the treatment is discontinued, symptoms might return within a period ranging from weeks to months. Moreover, special insurance approval may be necessary for acquiring these medications.